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CDT 10-K & 10-Q changes, risk factors and insider trading

CDT Equity Inc. (also CDTTW) · Nasdaq · Pharmaceutical Preparations · CIK 1896212 · All filings on SEC.gov

Everything below is quoted or computed from CDT Equity Inc.'s public SEC filings. It is not a recommendation to buy or sell. Automated comparisons can contain errors; confirm with the original filing.

At a glance

1 / 9risk-factor paragraphs added / removed in latest 10-K
0new risk-factor headings
0Form 4 filings reporting open-market purchases (last 180 days)
2Form 4 filings reporting open-market sales (last 180 days)

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What changed in the latest 10-K

Comparing 10-K filed 2026-04-15 (period ending 2025-12-31) with 10-K filed 2025-03-28 (period ending 2024-12-31).

Risk Factors (10-K Item 1A)

1new paragraphs
9removed paragraphs
14reworded paragraphs
16,864 → 15,861words in section

Removed heading “It is difficult to predict the time and cost of development and of subsequently obtaining regulatory approval for AZD1656 as it employs newly developed technology.”

Removed heading “We currently rely on agreements with third parties for the purpose of licensing our clinical assets. In the near-term, we intend to rely on third parties for the licensing of clinical assets and those which may arise through future partnerships.”

Largest changes (selected automatically by length and topic keywords; quoted verbatim, no commentary)

Removed text topics: delist, fine, liquidity
“If our common stock were to be delisted from trading on The Nasdaq Global Market and the trading price of our common stock were below $5.00 per share on the date the common stock is delisted, trading in our common stock would also be subject to the requirements of certain rules promulgated under the Exchange Act. …”
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Removed text topics: bankruptcy, labor
“If we raise additional funds by selling shares of our common stock or other equity-linked securities, the ownership interest of our current stockholders will be diluted. We may seek to access the public or private capital markets whenever conditions are favorable, even if we do not have an immediate need for additional capital at that time. …”
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Removed text topics: delist
“In August 2024, the Company received deficiency letters from Nasdaq notifying the Company that it was not in compliance with Listing Rule 5450(a)(1) (the “Bid Price Rule”), Listing Rule 5450(b)(2)(C) (the “MVPHS Rule”) and Listing Rule 5450(b)(2)(A) (the “MVLS Rule”, together with the Bid Price Rule and the MVPHS Rule, the “Rules”). The Company had until February 10, 2025, and February 11, 2025, to regain compliance with the Rules. On December 17, 2024, Nasdaq issued a letter to the Company that as of December 17, 2024, it determined that the Company’s securities had a closing bid price of $0. …”
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Removed text
“We currently rely on agreements with third parties for the purpose of licensing our clinical assets. In the near-term, we intend to rely on third parties for the licensing of clinical assets and those which may arise through future partnerships.”
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Removed text
“It is difficult to predict the time and cost of development and of subsequently obtaining regulatory approval for AZD1656 as it employs newly developed technology.”
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New text topics: litigation
“In November and December 2024, the Company received a letter from St George Street Capital and formal complaints filed with the Intellectual Property Office claiming the Company was assigned the US Application, and was not the sole owner, of the AZD 1656 co-crystal patent. In January 2025, Conduit issued a counter statement to the Intellectual Property Office disputing the claim filed by St George Street Capital. As of December 31, 2025, the damages sought by St George Street Capital are unknown and the potential contingency is not considered probable. …”
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Reworded

The report of our independent registered public accounting firm on the Company’s financial statements as of and for the year ended December 31, 2024,2025, includes an explanatory paragraph indicating that there is substantial doubt about our ability to continue as a going concern for at least one year from the date of filing. Through the date of the Business Combination, Old Conduit financed its working capital requirements by raising capital through private placements of its ordinary shares and issuing of short-term and convertible notes. The Company has financed its working capital requirements since the Business Combination primarily through the PIPE Financing (the “PIPE Financing”) completed in September 2023, and through issuing of short-term and convertible notes.notes, and via an at the market program with A.G.P./Alliance Global Partners.

Reworded

The scientific discoveries that form the basis for our efforts to generate and develop our clinical assets are relatively recent. AZD1656 is a glucokinase activator that is in a number of Phase II ready autoimmune disorders including uveitis, Hashimoto’s thyroiditis, preterm labor, and renal transplant, and the successful development of AZD1656 may require additional studies and efforts to optimize its therapeutic potential. In addition, our development pipeline includes what we believe to be a potent irreversible inhibitor of human Myeloperoxidase (MPO) that has the potential to treat idiopathic male infertility, which we refer to as AZD5904. AZD5904 may not demonstrate in patients the therapeutic properties ascribed to it in the laboratory or preclinical studies, and may interact with human biological systems in unforeseen, ineffective, or even harmful ways. If we are not able to successfully develop and commercialize our clinical assets, including AZD1656 and AZD5904, we may never become profitable and the value of our capital stock may decline. Additionally, Manoira may not be successful in evaluating the CDT Assets’ applicability in animal health, explore veterinary market opportunities related to AZD1656, and as such we may never develop and commercialize such assets.

Removed

It is difficult to predict the time and cost of development and of subsequently obtaining regulatory approval for AZD1656 as it employs newly developed technology.

Removed

AZD1656 uses a novel mechanism to reduce inflammation in many of the immune pathways. We have concentrated our research and development efforts of AZD1656 on a limited number of initial targeted disease indications for AZD1656. There can be no assurance that we will not experience problems or delays in developing our current or future indications for AZD1656 and that such problems or delays will not cause unanticipated costs, or that any such development problems can be solved. Moreover, AZD1656 would also represent a novel approach for the treatment of uveitis as steroids are currently the most common treatment for uveitis even though there are numerous side effects associated with the use of steroids. The clinical development of these novel technologies will require review and allowance by the FDA under an Investigational New Drug Application.

Reworded

WeWith the exception of our work at our Cambridge facilities, we do not currently have, nor do we plan to acquire, the infrastructure or capability to supply, manufacture, or distribute preclinical, clinical, or commercial quantities of drug substances or products. Our ability to develop our clinical assets depends and our ability to commercially supply our products will depend, in part, on our ability to successfully obtain the raw materials and APIs and other substances and materials used in our clinical assets from third parties and to have finished products manufactured by third parties in accordance with regulatory requirements and in sufficient quantities for preclinical and clinical testing and commercialization. If we fail to develop and maintain supply relationships with these third parties, we may be unable to continue to develop or commercialize our clinical assets.

Removed

We currently rely on agreements with third parties for the purpose of licensing our clinical assets. In the near-term, we intend to rely on third parties for the licensing of clinical assets and those which may arise through future partnerships.

Removed

We currently rely on agreements with third parties for the purpose of licensing clinical assets from large pharmaceutical companies. For example, we have agreements with AstraZeneca pursuant to which we license clinical assets from AstraZeneca. If we are in breach of the agreements, the termination of such agreement(s) could materially adversely affect our business, financial condition, operating results, and prospects. Our business strategy heavily depends on our ability to commercialize our clinical assets and our ability to enter into license agreements relating to such clinical assets is critical to the success of our operations

Reworded

Our ability to compete in the highly competitive pharmaceuticals industry depends upon our ability to attract and retain highly qualified managerial, scientific, medical, sales, marketing, and other personnel. We are highly dependent on our management, including our Chief Executive Officer, DavidAndrew Tapolczay.Regan. The loss of the services of any of these individuals could impede, delay, or prevent the successful development of our product pipeline, completion of our planned clinical trials, commercialization of our clinical assets, or in-licensing or acquisition of new assets and could negatively impact our ability to successfully implement our business plan. If we lose the services of any of these individuals, we might not be able to find suitable replacements on a timely basis or at all, and our business could be harmed as a result. We do not maintain “key man” insurance policies on the lives of these individuals or the lives of any of our other employees. In order to retain valuable employees, in addition to salary and cash incentives, we provide stock options that vest over time.

Reworded

We have registered the domain name for the website that we use in our business, which is www.conduitpharma.com.www.cdtequity.com. The inclusion of the website address in this Annual Report does not include or incorporate by reference the information on the Company’s website into this document.

Added

In November and December 2024, the Company received a letter from St George Street Capital and formal complaints filed with the Intellectual Property Office claiming the Company was assigned the US Application, and was not the sole owner, of the AZD 1656 co-crystal patent. In January 2025, Conduit issued a counter statement to the Intellectual Property Office disputing the claim filed by St George Street Capital. As of December 31, 2025, the damages sought by St George Street Capital are unknown and the potential contingency is not considered probable. As such, the Company has not accrued a loss contingency in the accompanying financial statements. We intend to vigorously defend against these claims. Regardless of its outcome, the litigation may impact our business due to, among other things, legal costs and the diversion of the attention of our management.

Reworded

In addition, in August 2023, prior to the Business Combination, our now wholly-owned subsidiary, Conduit Pharmaceuticals Limited, received a letter from Strand Hanson Limited (“Strand”) claiming it was owed advisory fees pursuant to a previously executed letter. Conduit Pharmaceuticals Limited rejected and disputed the substance of the letter in full. Following such rejection, on September 7, 2023, Strand filed a claim in the Business and Property Courts of England and Wales claiming it is entitled to be paid the sum of $2 million and, as a result of the event the Business Combination is completed, to be issued 65 thousand21 shares of common stock. WeOn intendDecember 16, 2025, the High Court of Justice, Business and Property Courts of England and Wales, ultimately ruled in favor of Strand, with a judgment amount payable from CPL to vigorouslyStrand defendtotaling against these$9.6 claims. Regardless of its outcome, the litigation may impact our business due to, among other things, defense legal cost and the diversion of the attention of our management.million.

Reworded

On December 12, 2024, we entered into the Sarborg Agreement with Sarborg. Under the terms of the Sarborg Agreement, Sarborg willagreed to provide algorithmic and cybernetic technology services to Conduit,CDT, including the development of decision-support tools and advanced cybernetic systems tailored to enhance Conduit’sCDT’s decision-making processes and maximize the value of its pharmaceutical asset portfolio.

Reworded

Sarborg willagreed to perform the services to ConduitCDT comprised of three phases: the Initial Phase (0-24 weeks) focuses on establishing a foundation for collaboration and aligning Sarborg’s services with Conduit’sCDT’s strategic goals; the Development Phase (24-36 weeks) involves building technological infrastructure, including dashboards and predictive models; and the Ongoing Services Phase (36-52 weeks) ensures the sustained functionality and relevance of Sarborg’s deliverables while supporting Conduit’sCDT’s growth through iterative improvements and updates. Sarborg will create specific deliverables, including reports, computer programs, software applications, APIs, mobile applications, source code, written technical specifications and designs, operating and maintenance manuals, and other recorded data and information arising from or relating to the services. Sarborg will provide all necessary resources to perform the services and deliver the deliverables in accordance with the Sarborg Agreement. To date, Sarborg has successfully completed all phases and has achieved all milestones provided for pursuant to the Sarborg Agreement.

Removed

To date, Conduit has successfully completed the Initial Phase of its collaboration with Sarborg, establishing a strong foundation for integrating AI-driven solutions into our operations. This phase focused on identifying key inputs for the algorithmic approach and ensuring alignment between Sarborg’s services and Conduit’s strategic goals. As part of this effort, Sarborg has successfully delivered three key milestones. First, they conducted detailed teach-in sessions with Conduit’s management team to gain a deeper understanding of our objectives, challenges, and operational workflows, resulting in documented meeting agendas, minutes, and action plans. Second, they finalized and validated a set of proprietary inputs essential for their cybernetic models, tailored specifically to Conduit’s portfolio and R&D pipeline. Finally, they completed an in-depth market analysis of potential cocrystal candidates, assessing the patent landscape, competitive positioning, and market size. The insights from this market analysis are now informing Conduit’s ongoing strategic decision-making. With these key milestones delivered, we are now progressing to the next phase of development.

Removed

Sarborg has now commenced Phase II: The Development Phase, which focuses on building the technological infrastructure necessary to integrate AI into Conduit’s operations. As part of this, Sarborg has successfully completed the first milestone, Dashboard Creation and Refinement, delivering personalized dashboards that provide Conduit’s key personnel with real-time access to critical data related to deliverables, clinical trials, and drug discovery. These initial dashboards, along with user interface mock-ups and a dashboard user guide, will serve as the foundation for further refinements. Moving forward, the platform will continue to be optimized to maximize efficiency and ensure seamless integration into Conduit’s workflows.

Reworded

As with many developing technologies, AI presents risks and challenges that could affect its further development, adoption, and use, and therefore our business. AI algorithms may be flawed or biased. Datasets used to train or develop AI systems may be insufficient, of inferior quality, or contain biased information. Additionally, the laws and regulations concerning the use of AI continue to evolve. If the use or integration of AI systems, or the outputs generated by such systems, were determined to be non-compliant (e.g., in relation to intellectual property or data privacy rights), this may result in liability, including legal liability, or adversely affect our business, reputation, brand, financial condition and results of operations. It is possible that emerging regulations may limit or block the use of AI in our business and solutions or otherwise impose other restrictions that may affect or impair the usability or efficiency of our business or services for an extended period of time or indefinitely. Our competitors or other third parties may incorporate AI into their product development, technology and infrastructure more quickly or more successfully than us, which could impair our ability to compete effectively and adversely affect our business, financial condition and results of operations. For more information on our dealings with Sarborg, see “Business- Principal Strategic Partnerships Services Agreement – CDT and Sarborg Limited”.

Removed

In August 2024, the Company received deficiency letters from Nasdaq notifying the Company that it was not in compliance with Listing Rule 5450(a)(1) (the “Bid Price Rule”), Listing Rule 5450(b)(2)(C) (the “MVPHS Rule”) and Listing Rule 5450(b)(2)(A) (the “MVLS Rule”, together with the Bid Price Rule and the MVPHS Rule, the “Rules”). The Company had until February 10, 2025, and February 11, 2025, to regain compliance with the Rules. On December 17, 2024, Nasdaq issued a letter to the Company that as of December 17, 2024, it determined that the Company’s securities had a closing bid price of $0.10 or less for ten consecutive trading days. As a result, Nasdaq had determined to delist the Company’s common stock and redeemable warrants from The Nasdaq Global Market, on December 27, 2024. The Company subsequently requested and received a hearing (the “Nasdaq Hearing”) from the Nasdaq Hearings Panel (the “Panel”). The Company submitted a written plan of compliance to cure its Rule deficiencies to Nasdaq on January 22, 2025, and attended the Nasdaq Hearing for the Company on February 11, 2025. On March 5, 2025, the Company received a written notification (the “Notice”) from the Panel confirming it has granted the Company such an extension for the Company to regain compliance with the MVPHS and MVLS rules, provided that the Company, (i) on or before March 12, 2025, files an application to transfer to the Nasdaq Capital Market, which application was submitted on March 7, 2025, and (ii) on or before March 31, 2025, demonstrates compliance with all Nasdaq listing rules, which it intends to do, and believes it will satisfy. Additionally, the Company was also notified in the Notice that as of February 26, 2025, it had regained compliance with the Bid Price Rule.

Reworded

FollowingThe the transfer to the Nasdaq Capital Market, the Company’s current MVPHS will be compliant with the MVPHS continued listing standard of greater than $1.0 million and the Company believes it will be able to demonstrate its compliance with the Equity Standard of Stockholder’s Equity greater than $2.5 million prior to the March 31, 2025, deadline to the satisfaction of Nasdaq, although no such assurance can be given. The inability to comply with Nasdaq’s continued requirements or standards could result in the delisting of our common stock, which could have a material adverse effect on our financial condition and could cause the value of the common stock to decline.

Removed

If our common stock were to be delisted from trading on The Nasdaq Global Market and the trading price of our common stock were below $5.00 per share on the date the common stock is delisted, trading in our common stock would also be subject to the requirements of certain rules promulgated under the Exchange Act. These rules require additional disclosure by broker-dealers in connection with any trades involving a stock defined as a “penny stock” and impose various sales practice requirements on broker-dealers who sell penny stocks to persons other than established customers and accredited investors, generally institutions. These additional requirements may discourage broker-dealers from effecting transactions in securities that are classified as penny stocks, which could severely limit the market price and liquidity of such securities and the ability of purchasers to sell such securities in the secondary market. A penny stock is defined generally as any non-exchange listed equity security that has a market price of less than $5.00 per share, subject to certain exceptions.

Reworded

The current expectation is that we will retain our future earnings to fund the development and growth of our business. As a result, capital capital appreciation, if any, of the shares of our common stock will be stockholders’ sole source of gain, if any, for the foreseeable future.

Removed

If we raise additional funds by selling shares of our common stock or other equity-linked securities, the ownership interest of our current stockholders will be diluted. We may seek to access the public or private capital markets whenever conditions are favorable, even if we do not have an immediate need for additional capital at that time. If we raise additional funds through collaborations, strategic alliances or marketing, distribution, or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, or clinical assets or to grant licenses on terms that may not be acceptable to us. If we raise additional funds through debt financing, we may have to grant a security interest on our assets to the future lenders, our debt service costs may be substantial, and the lenders may have a preferential position in connection with any future bankruptcy or liquidation involving the Company.

Reworded

On MarchApril 27,15, 2025,2026, the last quoted sale price for our common stock as reported on Nasdaq was $0.77$4.88 per share. Currently, the exercise prices of the Company’s warrantsPublic Warrants are significantly greater than the current market price of our common stock. Accordingly, such warrantsPublic Warrants are unlikely to be exercised and therefore the Company does not expect to receive any proceeds from such exercise of the warrants in the near term. Whether any holders of Public Warrants determine to exercise such warrants,Public Warrants, which would result in cash proceeds to the Company, will likely depend upon the market price of our common stock at the time of any such holder’s determination.

Reworded

We may issue additional shares of common stock or preferred stockstock, including issuances upon exercise of outstanding pre-funded warrants, in connection with capital raising transactions and under an employee incentive plan or under our existing at the market offering program, which would dilute the interest of our stockholders.

Reworded

We may issue a substantial number of additional shares of common or preferred stock pursuant to the exercise of previously issued pre-funded warrants, under an employee incentive plan or under our ongoing at the market offering program. The issuance of additional shares of common or preferred stock:

Management's Discussion & Analysis (MD&A) (10-K Item 7)

20new paragraphs
43removed paragraphs
21reworded paragraphs
7,362 → 5,658words in section

Removed heading “Nasdaq Stock Market Correspondence and Subsequent Nasdaq Capital Market Listing”

Removed heading “Promissory Convertible Note”

Removed heading “August 2024 Nirland Note”

Removed heading “October 2024 Nirland Note”

Removed heading “Fair Value of Warrants”

Removed heading “Stock-Based Compensation”

Largest changes (selected automatically by length and topic keywords; quoted verbatim, no commentary)

Removed text topics: default, penalt, regulation
“On November 22, 2024, the Company and Nirland entered into a Second Amendment to the August 2024 Nirland Note (the “Second Amendment”). Pursuant to the Second Amendment, the Nirland Note may not be converted (other than partial conversions that may be permitted pursuant to the rules and regulations of NASDAQ (or any successor entity)) prior to receipt of stockholder approval to provide for such conversion of the Nirland Note, and subsequent issuance of the Company’s Common Stock, pursuant to the stockholder approval rules under the rules and regulations of The Nasdaq Stock Market. …”
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Removed text topics: default, fine, interest rate
“On October 28, 2024, the Company issued a promissory note (the “October 2024 Nirland Note”) to Nirland in the original principal amount of $0.6 million in exchange for funds in such amount. The October 2024 Nirland Note bears interest at a rate of 12% per annum, is due and payable semi-annually in arrears, and matures on October 31, 2025. If an event of default under and as defined in the Nirland Note occurs, the interest rate will be increased to 18% per annum or to the maximum rate permitted by law. …”
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Removed text topics: default
“On October 9, 2024, the Company and the loan holder signed an extension for the March 2023 Convertible Note to extend the maturity date from September 20, 2024 to October 20, 2024 with the option for the Company to further extend the maturity date two times, each by an additional 30-day period. The Company exercised both options to extend the maturity date to December 19, 2024. As of December 31, 2024, the March 2023 Convertible Note is still outstanding and considered to be in default. …”
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Removed text topics: default
“In May 2022, we entered into two loan agreements (the “Loans”), with an aggregate principal amount of $0.2 million, with two lenders. The Loans were to mature and become payable in full two years from the date of the loan agreement and they bear no interest. On October 9, 2024, the Company executed agreements to extend the loan maturity date for each loan to December 19, 2024. As of December 31, 2024, the Loans are still outstanding and considered to be in default. The Company repaid the lenders in full during February 2025. …”
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Reworded topics: litigation

Paragraph as it now reads, with added and removed wording marked:

Net cash used in operating activities for the year ended December 31, 20232025 was $7.7$15.6 million, resulting primarily from a net loss of $0.5 $39.2 million, adjusteda gain foron non-cashthe itemswaiver includingof accrued interest of $0.4 million, a $4.3gain on debt extinguishment of $0.3 million reductionand ofa deferredgain income upon exercise ofon the Cizzle and Vela option, a $2.5 million change in fair value of warrant liabilities of $0.1 million. This was partially offset by a $7.0 million compensation expense from the issuance of shares and warrants upon the sale of a previously controlled subsidiary, $4.7 million cash inflow from operating assets and liabilities, a $2.3$3.2 million gaincash inflow from the issuance of common stock for services, a $2.7 million loss on the change in fair value of convertible notes payable, $2.4 million of amortization expense, $2.2 million cash outflow of stock-based compensation, $1.4 million of amortization of directors and officers insurance, a $0.4 million loss on the change in fair value of digital theassets, Vela and Cizzle options, a $0.2$0.3 million changeof innon-cash theinterest reserve for uncollectible loansexpense and a $0.1 million gain on warrant remeasurement, partially offset by a $1.0 million loss upon the issuance of thenon-cash Vela option, a $0.5 million change in amortization on directors & officers insurance, a $0.4 million loss on change in fair value of convertible notes and a $0.2 million increase in stock based compensationlease expense. The $2.5 $4.7 million cash outflow inflow from operating assets and liabilities iswas primarily duedriven toby a $1.0$9.6 million increase in accrued litigation liability, a $0.4 million cash inflow from accounts payable, partially offset by a $4.1 million cash outflow from prepaid expenses andexpenses, a $1.7$0.9 million cash outflow from accrued expenses and other liabilities, and other current liabilitiesassets partially offset byand a $0.2$0.1 million cash inflowoutflow from lease accounts payable.liabilities.
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Removed text
“Nasdaq Stock Market Correspondence and Subsequent Nasdaq Capital Market Listing”
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Reworded

The following discussion and analysis of our financial condition and results of operations should be read together with the other sections sections of this Annual Report on Form 10-K, including our audited financial statements for the year ended December 31, 2024, 2025, together with related notes thereto, included elsewhere in this Annual Report. The following discussion contains forward-looking statements based upon current expectations that involve risks, uncertainties, and assumptions. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of various factors, including those set forth under the section titled “Risk Factors” or in other parts of this Annual Report and our other filings with the SEC. Our historical results are not necessarily indicative of the results that may be expected for any period in the future. CDT Equity Inc. (formerly Conduit Pharmaceuticals Limited) entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Murphy Canyon Acquisition Corp. (“MURF”) on November 8, 2022. The transaction contemplated by the terms of the Merger Agreement was completed on September 22, 2023, in conjunction with which MURF changed its name to Conduit Pharmaceuticals Inc. (hereafter referred to, collectively with is subsidiaries as “ConduitCDT”, “CDT Equity”, the “Company”, “we”, “us” or “our”, unless the context otherwise requires. All dollar amounts are expressed in thousands of of United States dollars (“$”), unless otherwise indicated.

Reworded

On September 22, 2023, a merger transaction (the “Business Combination”) between Conduit Pharmaceuticals Limited (“Old Conduit”), Murphy Canyon Acquisition Corp (“MURF”) and Conduit Merger Sub, Inc., a Cayman Islands exempted company and a wholly owned subsidiary of MURF (“Merger Sub”), was completed pursuant to the Agreement and Plan of Merger, dated November 8, 2022, as amended, (the “Merger Agreement”). Pursuant to the terms of the Merger Agreement, at the closing, (i) Merger Sub merged with and into Old Conduit, with Old Conduit surviving the Business Combination as a wholly-owned subsidiary of MURF, and (ii) MURF changed its name from Murphy Canyon Acquisition Corp. to Conduit Pharmaceuticals Inc. Effective August 5, 2025, the Company changed its name from Conduit Pharmaceuticals Inc. to CDT Equity Inc. Our change to CDT Equity Inc. reflects the evolution of our strategy as a data-driven biotech development company focused on identifying, enhancing, and advancing high-potential therapeutic assets through scientific innovation and strategic partnerships.

Added

CDT Equity is a data-driven biotech development company focused on identifying, enhancing, and advancing high-potential therapeutic assets through scientific innovation and strategic partnerships. The Company has evolved into a broader, more agile platform that leverages artificial intelligence, solid-form chemistry, and efficient asset repositioning to accelerate the development of novel therapeutic treatments.

Added

CDT Equity’s strategy is centered on unlocking the untapped value of clinical-stage compounds, particularly those deprioritized by larger pharmaceutical companies with strong, supporting Phase I safety data. Through advanced co-crystallization and solid-form technologies developed at our Cambridge facility, we aim to improve drug properties and have successfully extended the patent life of certain drugs by up to 20 years.

Removed

Conduit has developed a unique business model that allows it to act as a conduit to bring clinical assets from pharmaceutical companies and develop new treatments for patients. Our novel approach addresses unmet medical needs and lengthens the intellectual property for our existing assets through cutting-edge solid-form technology and then commercializing these products with life science companies. We continue to evaluate novel artificial intelligence and cybernetics approaches to drug re-purposing, intellectual property and asset selection to give Conduit a competitive advantage.

Removed

We are led by highly experienced pharmaceutical executives: Dr. Freda Lewis-Hall, former Chief Medical Officer of Pfizer Inc., the Chair of our Board of Directors, and Dr. David Tapolczay, former Chief Executive Officer of the United Kingdom-based medical research charity LifeArc, our Chief Executive Officer. Our management team includes active senior scientists who have an extensive understanding of the pharmaceuticals market, which supports our strategy of developing clinical assets in a cost-efficient manner while focusing on therapeutic efficacy and patient safety.

Reworded

Simultaneously,Our Conduitcurrent leveragespipeline theincludes capabilitiescandidates oftargeting our Cambridge laboratory facilityinflammatory and highlyautoimmune experienceddisorders, teamas ofwell solid-formas expertsidiopathic tomale extend orinfertility, develop proprietary solid-form intellectual property for our existingdermatology, and futureanimal clinicalhealth. assets. Our ownThe intellectual property portfolio comprises pending patent applications in several international jurisdictions describing a solid-form compound, including the AZD1656 Cocrystal (a HK-4 Glucokinase Activator), targeting a wide range of autoimmune disorders.. Our pipeline research includes a number of additional compounds that serve as promising alternatives to existing clinical assets currently marketed and sold by large pharmaceutical companies, which we have identified as havingpotential an opportunityopportunities to develop further intellectual property positions through solid-form technology.

Added

Our collaboration with Sarborg enables us to apply proprietary algorithms utilizing AI-powered disease mapping to identify novel re-purposing opportunities across a database of more than 3,000 disease signatures. Sarborg’s insights have directly informed two new combination patent filings, strengthening our intellectual property portfolio. In addition, CDT Equity has initiated pre-clinical in-vitro models to explore new indications, guided by AI-insights without human intervention. We will seek an exit through third-party license deals following successful in vitro and in vivo pre-clinical trials, entering into agreements with third parties to pursue further development, FDA approval, commercialization, and marketing of our assets.

Removed

In connection with the funding and development of clinical assets, we expect to evaluate and select the specific molecules to be developed and collaborate with external CROs and Key Opinion Leaders (“KOLs”) to run clinical trials that are managed, funded, and overseen by us. We intend to leverage our comprehensive clinical and scientific expertise in order to facilitate development of clinical assets through Phase II trials in an efficient manner by using CROs and third-party service providers. We will also collaborate closely with disease specific KOLs to collectively assess and determine the most appropriate indications for all our current and forthcoming assets.

Removed

We believe that successful Phase II trials of the clinical assets in our pipeline will increase the value of our assets. There is no assurance that any clinical trials on the assets owned or licensed by us will be successful, however, following a successful Phase II clinical trial, we would look to licensing opportunities with large biotech or pharmaceutical companies, typically for up-front milestone payments and royalty income streams for the life of the asset patent. We anticipate using any future royalty income stream to develop our asset portfolio in combination with other potential sources of financing, including debt or equity financing.

Removed

Outside of our proprietary owned patented clinical assets, AstraZeneca agreed to grant a license to the Company under certain intellectual property rights controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for the development and commercialization of the Licensed Products under the related License Agreement. The Company is required to use commercially reasonable efforts to develop and commercialize the Licensed Products.

Removed

AstraZeneca has conducted initial pre-clinical and, in some instances, clinical trials on these assets, but has decided to license them for further development. As the clinical assets have undergone initial pre-clinical and clinical testing conducted by AstraZeneca, we are able to use the safety data generated in these clinical trials to assess which clinical assets to further develop and for which indications.

Removed

Through this relationship, there are considerable APIs that were manufactured by AstraZeneca (prior to conducting its clinical trials) available to Conduit. As a result, Conduit may not have to develop the APIs, which is often a time consuming and expensive process, and the APIs already produced were subject to rigorous quality control measures.

Removed

In collaboration with SARBORG Limited (“Sarborg”), a related party, Conduit intends to leverage an advanced AI and cybernetics platform to evaluate key deliverables across multiple areas of the Company’s operations, including drug repurposing, drug discovery, solid-form identification, and clinical trial monitoring.

Reworded

The Sarborg Agreement entered into between the Company and Sarborg on December 12, 2024 is designed to address longstanding challenges in the pharmaceutical sector, in particular by reducing human error in critical decision-making processes in both clinical development and asset identification. By integrating Sarborg’s algorithmic AI/cybernetics technology, ConduitCDT Equity aims to enhance efficiency, lower costs, and accelerate timelines by minimizing human intervention, ultimately optimizing the drug development cycle and giving ConduitCDT Equity a competitive advantage in the sector.

Reworded

Through this relationship, ConduitCDT Equity will gain access to cutting-edge predictive models and dashboards, enabling the Company to evaluate drug candidates, candidates, streamline clinical trials, and optimize asset management with real-time data. These tools will drive faster, more accurate decisions, decisions, improving efficiency and reducing costs. By leveraging these insights, ConduitCDT Equity can differentiate itself in a competitive sector and gain unique data-driven insights that position the Company for success across both its current and future asset portfolio.

Added

A further partnership with Manoira enables CDT Equity to expand the scope of its drug portfolio into the animal health market in a cost-efficient manner. This collaboration allows us to accelerate the understanding of the mechanism of action, safety, and potential efficacy of its portfolio across multiple species, while retaining 100% ownership of all data and intellectual property generated relating to human applications. This is expected to enhance the core human therapeutic pipeline but also opens potential new revenue streams in the high-growth veterinary market.

Added

Repositioning CDT Equity enables the Company to explore multiple opportunities in the healthcare, biotech, artificial intelligence and broader technology innovation. The Board continues to evaluate an artificial intelligence led strategy, collaborating with consultants to best advise a growing market which has seen significant recent activity and success for respective stakeholders. Long-term exposure to artificial intelligence can present both strategic and financial benefits as part of a diversified capital management approach.

Added

Operating with a lean disease-agnostic model, CDT Equity prioritizes speed, adaptability, and capital efficiency. We avoid the cost burden of late-stage clinical trials, focusing instead on high-leverage development strategies. Led by highly experienced executives: Dr. Freda Lewis-Hall, former Chief Medical Officer of Pfizer Inc., the Chair of the Company’s Board; Dr. Andrew Regan, CEO and James Bligh, CFO. Our management team includes active senior scientists who have an extensive understanding of the pharmaceuticals market, supporting our strategy of developing clinical assets in a cost-efficient manner focused on therapeutic efficacy.

Added

In 2024, AstraZeneca granted a license to the Company under certain intellectual property rights controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for development and commercialization of the Licensed Products under the related License Agreement. The Company is required to use commercially reasonable efforts to develop and commercialize the Licensed Products.

Added

AstraZeneca has conducted initial pre-clinical and, in some instances, clinical trials on these assets, but has decided to license them for further development. As the clinical assets have undergone initial pre-clinical and clinical testing conducted by AstraZeneca, we are able to use the safety data generated in these clinical trials to assess which clinical assets to further develop and re-purpose.

Removed

In addition, Conduit will retain a perpetual, non-exclusive, royalty-free, and assignable right to use any platform or technology developed by Sarborg in association with the deliverables. Ongoing support from Sarborg will ensure these systems evolve with Conduit’s needs, driving long-term innovation in areas like IP creation, regulatory strategy, and clinical trial monitoring. This partnership reinforces Conduit’s commitment to leveraging AI-driven solutions to accelerate growth, deliver value to shareholders, and maintain a competitive edge in the pharmaceutical sector.

Removed

This strategic move reaffirms Conduit’s commitment to adopting forward-thinking solutions to stay at the forefront of innovation in the pharmaceutical industry. By reducing reliance on traditional, labor-intensive methods and harnessing the power of AI-driven technology, Conduit is well-positioned to lead in areas such as drug repurposing, clinical trial monitoring, and IP creation, ensuring the Company’s long-term growth and market leadership.

Reworded

Furthermore, ConduitCDT Equity is well positioned to pursue, and intends to pursue,pursue additional relationships and/or partnerships with third parties forto thelicense licensing of further assets which are currently deprioritized. We plan to focus our efforts on developing clinical assets to address disorders that impact a large populationpopulations where there is no present treatment or the presentexisting treatment,treatments carriescarry significant unwanted side effects.

Added

During the year ended December 31, 2025, the Company effected three reverse stock splits of its common stock pursuant to amendments to the Company’s Second Amended and Restated Certificate of Incorporation that were previously approved by the Company’s stockholders and authorized by the Board of Directors. The reverse stock splits were implemented as follows: a 1-for-100 reverse stock split effective January 24, 2025, a 1-for-15 reverse stock split effective May 19, 2025, and a 1-for-8 reverse stock split effective October 10, 2025.

Added

On March 26, 2026, the company effected a 1-for-25 reverse stock split. No fractional shares were issued in connection with the reverse stock splits. Stockholders who otherwise would have been entitled to receive fractional shares received cash in lieu of fractional shares based on the applicable post-split trading price of the Company’s common stock. All references to numbers of shares of common stock and per-share information in this Annual Report on Form 10-K have been adjusted retroactively, as appropriate, to reflect the reverse stock split.

Added

Reverse stock splits were applied sequentially at their respective effective dates (resulting in a cumulative effect equivalent to an approximate 1-for-300,000 reverse stock split).

Added

The reverse stock splits automatically combined the Company’s issued and outstanding shares of common stock at the applicable ratios without affecting the number of authorized shares of common stock or the par value of $0.0001 per share. No fractional shares were issued in connection with the reverse stock splits. Stockholders who otherwise would have been entitled to receive fractional shares received cash in lieu of fractional shares based on the applicable post-split trading price of the Company’s common stock.

Removed

On January 22, 2025, we filed a certificate of amendment to the Company’s Second Amended and Restated Certificate of Incorporation (the “Amendment”) with the Secretary of State of the State of Delaware to effectuate a 1-for-100 reverse stock split (the “Reverse Stock Split”) of the outstanding shares of our common stock. Our stockholders previously approved the Reverse Stock Split and granted the board of directors the authority to determine the exact split ratio and when to proceed with the Reverse Stock Split at our annual meeting of stockholders held on December 18, 2024. The Reverse Stock Split became effective on January 24, 2025, and the common stock begin trading on The Nasdaq Global Market on a Reverse Stock Split-adjusted basis on January 27, 2025. The par value and other terms of the common stock were not affected by the Reverse Stock Split.

Reworded

As a result of the aggregate of the reverse stock split,splits, every 100300,000 shares of our common stock issued or outstanding were automatically reclassified into and became one new share of common stock,stock. and theThe number of our issued and outstanding shares of common stock, when accounting for the reverse stock splits, was reduced92,140 to 1,384,801 and 738,295461 shares as of December 31, 20242025 and December 31, 2023,2024, respectively. All references to numbers of shares of common stock and per-share information in this Annual Report on Form 10-K have been adjusted retroactively, as appropriate, to reflect the reverse stock split.

Added

In accordance with ASC 260, Earnings Per Share, all historical share and per-share amounts presented in the accompanying consolidated financial statements and related notes have been retroactively adjusted to reflect the effect of the reverse stock splits for all periods presented. Accordingly, all references to common stock share amounts and per-share information in this Annual Report on Form 10-K have been retroactively adjusted, as applicable, to reflect the reverse stock splits.

Removed

Nasdaq Stock Market Correspondence and Subsequent Nasdaq Capital Market Listing

Removed

We are compliant with the MVPHS continued listing standard of Nasdaq Capital Market being greater than $1.0 million. The current MVPHS is $5,166,785 based on the closing price of the common stock on March 27, 2025.

Removed

On a pro-forma basis at March 31, 2025, we expect to satisfy compliance with the Nasdaq Capital Market Equity Standard of Stockholder’s Equity greater than $2.5 million, after anticipating all Q1 2025 expected losses. Through the date of the consolidated financial statements, Stockholder’s Equity has increased significantly, through (i) fundraising of an additional $8.332 million from the Sales Agreement with AGP, (ii) conversion of $1.785 million from the Nirland Notes into 924,200 shares of common stock, and (iii) capitalization of certain invoices and fees. We expect to maintain continued compliance with the Equity Standard through additional issuance under its Sales Agreement, additional conversions of outstanding debt and capitalization of fees and a tight control of expenditure, although no such assurance can be given.

Added

Research and development expenses increased by approximately $1.7 million, or 50%, to approximately $5.1 million for the year ended December 31, 2025, as compared to approximately $3.4 million for the year ended December 31, 2024. The increase was primarily driven by an increase of $4.2 million related to work performed under the Sarborg agreements, a $0.3 million increase related to Thesprogen, a $0.2 million increase related to Charles River and a $0.1 million increase related to Manoira, partially offset by a $3.1 million decrease related to an upfront payment to AstraZeneca with no comparable activity in 2025.

Removed

Research and development expenses increased by approximately $3.3 million, or 3,653%, to approximately $3.4 million for the year ended December 31, 2024, as compared to approximately $90 thousand for the year ended December 31, 2023. The increase was primarily driven by a $3.1 million upfront payment to AstraZeneca in connection with the license agreement, comprised of $1.5 million cash and $1.6 million of our common shares issued to AstraZeneca with no comparable activity in 2023.

Added

General and administrative expenses increased by $19.7 million, or 163%, to approximately $31.7 million for the year ended December 31, 2025, as compared to approximately $12.0 million for the year ended December 31, 2024. The $19.7 million increase was primarily driven by a $9.6 million increase in litigation liability expense in relation to the Strand litigation, a $7.0 million increase in compensation expense associated with the issuance of common stock and pre-funded warrants as consideration for the sale of CPL, a $2.4 million increase in legal fees, and a $0.9 million increase in salaries and stock-based compensation, partially offset by a $0.2 million decrease in directors’ and officers’ (D&O) insurance costs.

Removed

General and administrative expenses increased by $6.9 million, or 133%, to approximately $12.0 million for the year ended December 31, 2024, as compared to approximately $5.2 million for the year ended December 31, 2023. The increase was primarily driven by a $3.4 million increase in salaries, stock-based compensation and payroll, a $1.3 million increase in other G&A expenses, a $1.1 million increase in D&O insurance, a $0.5 million increase in professional fees including: legal fees, accounting and tax expense, listing fees and consulting fees and a $0.5 million increase in travel expenses.

Reworded

Other income (expense),expense, net

Added

Activity for the year ended December 31, 2025 consisted of a loss on the change in fair value of convertible notes of $2.7 million, a loss on the disposition of digital assets of $0.4 million, partially offset by a gain on the waiver of accrued interest of $0.4 million, a gain on debt extinguishment of $0.3 million, and a gain on the change in the fair value of warrant liability of $0.2 million.

Added

Activity for the year ended December 31, 2024 consisted of a loss of debt extinguishment of $3.2 million and a loss on the issuance of warrants for lock-up of $2.7 million, partially offset by a gain on debt extinguishment of $2.5 million, a gain on the change in fair value of convertible notes of $2.0 million, a $0.3 million income tax refund and a gain on the change in the fair value of warrant liability of $0.2 million.

Removed

Other income (expense), net changed by $5.8 million, or 118%, to other expense of approximately $0.9 million for the year ended December 31, 2024, as compared to other income of $4.9 million for the year ended December 31, 2023. In 2024, other expense was driven by a $2.7 million loss on the issuance of warrants, and a $0.7 million expense related to a net loss on extinguishments, offset by a $2.0 million gain on the change in fair value of convertible notes payable, a $0.3 million increase from an income tax refund and a $0.2 million increase in the gain on change in fair value of warrants. In 2023, other income was driven by a $1.5 million gain on the derecognition of the Cizzle option in 2023, a $1.3 million gain on the change in fair value of the Cizzle option, a $2.8 million gain on the derecognition of the deferred revenue for the Vela option prior to the exercise of the Vela option, and a $1.0 million gain on the change in fair value of the Vela option. This was offset by a $1.0 million loss on issuance related to the Vela option, $0.4 million change in the fair value of convertible notes payable and $0.3 million realized foreign currency transaction loss.

Reworded

For further details refer to Note 1717, “Other income (expense), net,” in the consolidated financial statements as of December 31, 20242025 and 20232024 included elsewhere in this Annual Report.

Reworded

Interest expense, net changed by $1.3$1.2 million or 614%,79%, to $1.5$0.3 million for the year ended December 31, 2024,2025, from $0.2$1.5 million for the year ended ended December 31, 2023.2024. The changedecrease was drivenprimarily byattributable to a $0.9 million increasedecrease in the amortization of debt issuance costscosts, debt discounts, and debt discountsconversion costs, and a $0.4 million increasedecrease in interest expense incurredand onconversion costs related to interest-bearing convertible promissory notes.notes, partially offset by a $0.1 million increase in loan settlement fees.

Reworded

Our primary uses of cash are to fund our operations as we continue to grow our business. We will require a significant amount of cash for for expenditures as we invest in ongoing research and development and business operations. Until such time we can generate significant revenue from the successful approval and commercialization of a product candidate, we expect to finance our cash needs for ongoing research and development and business operations through public or private equity or debt financings or other capital sources, including strategic partnerships. However, we may be unable to raise additional funds or enter into such other arrangements, when needed, on favorable terms or at all. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our stockholders will be, or could be, diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our common stockholders. Debt financing and equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, or substantially reduce research and development efforts all of which could have a material adverse effect on the Company and its financial results.

Removed

Loans Payable

Removed

In May 2022, we entered into two loan agreements (the “Loans”), with an aggregate principal amount of $0.2 million, with two lenders. The Loans were to mature and become payable in full two years from the date of the loan agreement and they bear no interest. On October 9, 2024, the Company executed agreements to extend the loan maturity date for each loan to December 19, 2024. As of December 31, 2024, the Loans are still outstanding and considered to be in default. The Company repaid the lenders in full during February 2025. Refer to Note 8 to our financial statements included elsewhere in this Annual Report.

Removed

Promissory Convertible Note

Removed

In March 2023, we issued an aggregate principal amount of $0.8 million convertible promissory note (the “March 2023 Convertible Note”) payable to an investor.

Removed

The March 2023 Convertible Note originally was to mature and become payable in full, 18 months from the date of the March 2023 Convertible Note. The March 2023 Convertible Note carries 20% interest per annum and interest is payable every six months from the date of the March 2023 Convertible Note until the maturity date. The March 2023 Convertible Note became convertible into Common Stock following the consummation of the Merger.

Removed

On October 9, 2024, the Company and the loan holder signed an extension for the March 2023 Convertible Note to extend the maturity date from September 20, 2024 to October 20, 2024 with the option for the Company to further extend the maturity date two times, each by an additional 30-day period. The Company exercised both options to extend the maturity date to December 19, 2024. As of December 31, 2024, the March 2023 Convertible Note is still outstanding and considered to be in default. On March 6, 2025, the Company reached an agreement with the loan holder to pay $0.7 million in order to settle the March 2023 Convertible Note in full. The Company repaid the loan holder the settlement amount $0.7 million on March 13, 2025. Refer to Note 7 to our financial statements included elsewhere in this Annual Report.

Reworded

At any time prior to the full payment of the A.G.P. Convertible Note, provided that the A.G.P. has given at least three business days written written notice to the Company, A.G.P., in its sole discretion, may elect to have all or any portion of the outstanding principal amount and all interest accrued converted into shares of the Company’s common stock, at the lower of the Reverse Split price and the market price price per share at the time of the conversion date, but in no event less than $1.00, subject to adjustment as provided therein and to take take into account any future share splits or reverse splits. However, the conversion of the A.G.P. Convertible Note may not occur prior to the Company having sufficiently authorized shares of common stock to permit the entire conversion of the convertible promissory note. note. Refer to Note 8 to our financial statements included elsewhere in this Annual Report. Per the terms outlined in the agreement, we are required to undertake capital raises to paydown the A.G.P. Convertible Note.

Added

During the year ended December 31, 2025, the holder of the A.G.P. Convertible Note converted $3.5 million of principal and interest into 18,711 shares of the Company’s Common Stock, respectively. As of December 31, 2025 and the date of filing the consolidated financial statements, approximately $2.5 million and $1.2 million, respectively, of principal and interest remained outstanding under the A.G.P. Convertible Note.

Removed

August 2024 Nirland Note

Removed

On August 6, 2024, the Company entered into a Senior Secured Promissory Note (the “August 2024 Nirland Note”) with Nirland, a related party of the Company, pursuant to which the Company issued and sold to Nirland the August 2024 Note in the original principal amount of $2,650,000, inclusive of a $500,000 original issuance discount. Refer to Note 8 to our financial statements included elsewhere in this Annual Report.

Removed

On October 31, 2024, the Company and Nirland amended the August 2024 Nirland Note, whereby the August 2024 Nirland Note was amended to (i) provide for the conversion of the August 2024 Nirland Note into shares of Common Stock, at Nirland’s discretion, in a multiple of any unpaid amounts, if not otherwise previously paid, pursuant to the conversion rate contained therein, (ii) remove Nirland’s Mandatory Prepayment Right, and (iii) remove Nirland’s right of first refusal to participate in any future equity or debt offerings of the Company. The number of shares of Common Stock issuable upon conversion of any Conversion Amount pursuant to shall be determined by dividing (x) such conversion amount by (y) the conversion price. Conversion amount means two and one quarter times the sum of (x) portion of the principal to be converted, redeemed or otherwise with respect to which this determination is being made and (y) all accrued and unpaid interest with respect to such portion of the principal amount, if any. Conversion price means, as of any conversion date or other date of determination, $10, subject to adjustment as provided within the amended agreement. Note 7 to our financial statements included elsewhere in this Annual Report.

Removed

On November 22, 2024, the Company and Nirland entered into a Second Amendment to the August 2024 Nirland Note (the “Second Amendment”). Pursuant to the Second Amendment, the Nirland Note may not be converted (other than partial conversions that may be permitted pursuant to the rules and regulations of NASDAQ (or any successor entity)) prior to receipt of stockholder approval to provide for such conversion of the Nirland Note, and subsequent issuance of the Company’s Common Stock, pursuant to the stockholder approval rules under the rules and regulations of The Nasdaq Stock Market. If the Company has not held a special meeting of the stockholders to approve the full conversion of the August 2024 Nirland Note on or before January 9, 2025, then the Company shall be obligated to pay Nirland a penalty of $100,000 per day until the special meeting is held. The special meeting was held on January 9, 2025, in which stockholder approval was obtained. In addition, the existing conversion rate was amended to be two and one half times the sum of (x) the portion of the principal to be converted, redeemed or otherwise with respect to which this determination is being made and (y) all accrued and unpaid interest (including default interest) with respect to such portion of the principal amount, if any divided by $0.10, pre-split in January 2025 (or following any reverse splits that may occur in a ratio greater than 10 to 1, the lower of such reverse split price and the market price per share at the time of the conversion date, but in no event less than $1.00), subject to adjustment as provided therein and to take into account any future share splits or reverse splits. On January 24, 2025, the Reverse Stock Split became effective, resulting in every 100 shares of our common stock issued or outstanding becoming one new share of our common stock, resulting in the conversion price increasing to $6.86 as of December 31, 2024.

Removed

On December 9, 2024, Nirland exercised their conversion option and converted $0.1 million of principal for 23,000 shares of common stock pursuant to the rules and regulations of the NASDAQ. As of December 31, 2024, $2.6 million of principal and accrued interest remains outstanding.

Removed

October 2024 Nirland Note

Removed

On October 28, 2024, the Company issued a promissory note (the “October 2024 Nirland Note”) to Nirland in the original principal amount of $0.6 million in exchange for funds in such amount. The October 2024 Nirland Note bears interest at a rate of 12% per annum, is due and payable semi-annually in arrears, and matures on October 31, 2025. If an event of default under and as defined in the Nirland Note occurs, the interest rate will be increased to 18% per annum or to the maximum rate permitted by law. In connection with the Nirland Note, the Company has agreed to pay Nirland a 1% arrangement fee, which will be included with the principal and interest owed under the Nirland Note. The Company paid down $0.2 million of the October 2024 Nirland Note on December 11, 2024 and as of the date of filing this Annual Report, such note has been repaid in full. Refer to Note 8 and Note 20 to our financial statements included elsewhere in this Annual Report.

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What changed in the latest 10-Q

Comparing 10-Q filed 2026-08-12 (period ending 2026-06-30) with 10-Q filed 2026-07-15 (period ending 2026-03-31).

Risk Factors (10-Q Part II, Item 1A)

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Management's Discussion & Analysis (MD&A) (10-Q Part I, Item 2)

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New heading “Comparison of the Six Months Ended June 30, 2026 and 2025”

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New heading “Loss on Investment”

New heading “Interest Expense, Net”

New heading “Second Amendment to J.J. Astor Convertible Note”

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New text topics: default, restructuring, interest rate
“In connection with the accommodation, the total principal balance was increased by a $378,000 restructuring premium, to a total amended principal balance due to J.J. Astor of $2.3 million and increased the default interest rate from 19% to 24% per annum upon any future event of default. The J.J. Astor Note is now payable in 23 weekly installments of approximately $104,000 commencing August 14, 2026 through a new maturity date of January 15, 2027.”
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New text topics: default
“Under this amendment, the lender agreed to treat these matters as an accommodation, rather than an event of default, but expressly reserved all rights if any future payment default occurs.”
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“Comparison of the Six Months Ended June 30, 2026 and 2025”
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“Second Amendment to J.J. Astor Convertible Note”
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Reworded

On December 12, 2024, Sarborg and the Company entered into an agreement (the “Sarborg Agreement”) designed to address longstanding longstanding challenges in the pharmaceutical sector, in particular by reducing human error in critical decision-making processes in both clinical development and asset identification. By integrating Sarborg’s signature intelligence technology, the Company aims to enhance efficiency, lower costs, and accelerate timelines by minimizing human intervention, ultimately optimizing the drug development cycle and giving the Company a competitive advantage in the sector. Through this relationship, the Company will gain access to cutting-edge predictive models and dashboards, enabling the Company to evaluate drug candidates, streamline clinical trials, and optimize asset management with real-time data. These tools will drive faster, more accurate decisions, improving efficiency and reducing costs. By leveraging these insights, the Company can differentiate itself in a competitive sector and gain unique data-driven insights that position the Company for success across both its current and future asset portfolio. Our collaboration with Sarborg enables us to apply proprietary algorithms utilizing AI-powered disease mapping to identify novel re-purposing opportunities across a database of more than 3,000 disease signatures. Sarborg’s insights have directly informed two new combination patent filings, strengthening our intellectual property portfolio. In addition, the Company has initiated pre-clinical in-vitro models to explore new indications, guided by AI-insights without human intervention. We will seek an exit through third-party license deals following successful in vitro and in vivo pre-clinical trials, entering into agreements with third parties to pursue further development, FDA approval, commercialization, and marketing of our assets. We continue to evaluate novel novel artificial intelligence and cybernetics approaches to drug re-purposing, intellectual property, and asset selection to give the Company a competitive advantage. Sarborg is considered to be a related party of CDT, as Dr. Andrew Regan, Chief Executive Officer of CDT, also sits on the board of directors of Sarborg,Sarborg and is a shareholder of Sarborg through his ownership of Corvus, Chele Chiavacci Farley, a director of CDT is also a shareholder of Sarborg and Ulrik Olsen, a director of CDT is also a shareholder of Sarborg.

Reworded

The Company effected fourfive reverse stock splits of its common stock pursuant to amendments to the Company’s Second Amended and Restated Certificate of Incorporation that were previously approved by the Company’s stockholders and authorized by the Board of Directors. The reverse stock splits were implemented as follows: a 1-for-100 reverse stock split effective January 24, 2025, a 1-for-15 reverse reverse stock split effective May 19, 2025, a 1-for-8 reverse stock split effective October 10, 2025 and2025, a 1-for-25 reverse stock split effective effective March 26, 2026, a 1-for-10 reverse stock split effective July 20, 2026.

Reworded

As a result of the aggregate of the reverse stock splits, every 300,0003,000,000 shares of our common stock issued or outstanding were automatically reclassified into and became one new share of common stock. The number of our issued and outstanding shares of common stock, when accounting for the reverse stock splits, was 4,722,457631,080 and 92,1409,214 shares as of MarchJune 31,30, 2026 and December 31, 2025, respectively.

Reworded

We incurred approximately $0.8$0.3 million and $0.9$1.1 million on research and development activities during the three and six months ended MarchJune 30, 31, 20262026, respectively. We incurred approximately $1.8 million and March$2.8 31,million on research and development activities during the three and six months ended June 30, 2025, respectively. Our research and development activities have been focused on developing co-crystals of of AZD1656 to increase patent life as well as purchasing technology to help us determine the feasibility that AZD1656, and potentially other de-prioritized assets, may reach commercialization. Some of this work was completed by third-party CROs but all intellectual property property is retained by us. We currently have one pending international patent application and two pending national patent applications. The successful completion of clinical trials increases the value of clinical assets and may lead to the commercialization and/or licensing of such assets to other pharmaceutical companies. There is no assurance that any clinical trials on the assets owned or licensed by us will be successful.

Reworded

Other income (expenses), net consists of change in the fair value of options, change in fair value of convertible notes, change in fair value of digital assetsnotes and expense incurred upon the issuance of warrants during the threesix months ended MarchJune 31,30, 2026.

Reworded

Comparison of the Three Months Ended MarchJune 31,30, 2026 and 2025

Reworded

Research and development expenses decreased by $0.1$1.6 million, or 15%,84%, to $0.8$0.3 million for the three months ended MarchJune 31,30, 2026, as compared to to $0.9$1.9 million for the three months ended MarchJune 31,30, 2025. The decrease was primarily attributable to a $0.2$1.5 million decrease in expense expense related to our transactions with Sarborg and a $0.1 million decrease related to Charles River activity. The decrease was partially offset by an increase of $0.1 million related to the Thesprogen agreement entered into during 2026the andthree anmonths increaseended June of30, $48 thousand related to a third-party consultant’s research and development activity.2026.

Added

General and administrative expenses decreased by $0.4 million, or 13%, to $2.7 million for the three months ended June 30, 2026, compared to $3.1 million for the three months ended June 30, 2025. The decrease was primarily driven by a $0.6 million decrease in legal and professional fees, and a $0.3 million decrease in salaries and stock-based compensation and $0.1 million decrease in insurance expense, partially offset by a $0.3 million increase in audit and accounting fees and a $0.3 million increase in other general and administrative expenses.

Removed

General and administrative expenses increased by $0.2 million, or 7%, to $2.9 million for the three months ended March 31, 2026, compared to $2.7 million for the three months ended March 31, 2025. The increase was primarily driven by a $0.2 million increase in audit and accounting fees and a $0.2 million increase in travel expense, partially offset by a $0.2 million decrease in salaries and stock based compensation, a $0.1 million decrease in insurance expense and a $47 thousand decrease in legal expense.

Reworded

Other expense, net decreasedincreased by $0.7$0.5 million or 70%,50%, to $0.3$1.5 million for the three months ended MarchJune 31,30, 2026, compared to a $1.0 million for for the three months ended MarchJune 31,30, 2025. The decreaseincrease was primarily driven by a decrease of $1.6$0.2 million of expense forrelated theto netconversions and changes in fair value of convertible notes payable,payable partially offset by $0.4 million change in the gain uponand a waiver of accrued interest, $0.3 million change in gain loss upon debt extinguishment, $0.1 million change on the gain on change in the fair value of warrants, and a $0.1 million change on the gain on the issuance of shares for services.extinguishment.

Reworded

For further details refer to Note 14 in the unaudited condensed consolidated financial statements for the three months ended March 31, 2026 and March 31, 2025 included elsewhere in this document.

Reworded

Loss on equity method investments was $0.1 million for the three months ended MarchJune 31,30, 2026. The loss was driven by a loss on the change in the carrying value of our investment in Sarborg with no comparable activity during the three months ended MarchJune 31,30, 2025.

Reworded

Interest expense, net decreased by $0.1 million,$40,000, or 72%,70%, to $0.1 million$17,000 for the three months ended MarchJune 31,30, 2026, as compared to $0.2 million$57,000 for the three months ended MarchJune 31,30, 2025. The decrease was driven by a decrease of the principal outstanding on the A.G.P. Convertible Note as a result of conversions, decrease of the principal outstanding on the August 2024 Nirland Note and October 2025 Nirland Note as a result of conversions and repayment in fullsettlement during the three months ended MarchJune 31, 2025, and a decrease of $65 thousand of debt issuance cost amortization related to the Convertible Promissory Note Payable, partially offset by $23 thousand of interest expense related to the Ascent Note which was entered into during the three months ended March 31,30, 2026.

Added

Comparison of the Six Months Ended June 30, 2026 and 2025

Added

Research and Development Expenses

Added

Research and development expenses decreased by $1.7 million, or 61%, to $1.1 million for the six months ended June 30, 2026, as compared to $2.8 million for the six months ended June 30, 2025. The decrease was primarily attributable to a $1.7 million decrease in expense related to research and development activity with Sarborg.

Added

General and Administrative Expenses

Added

General and administrative expenses decreased by $0.2 million, or 4%, to $5.6 million for the six months ended June 30, 2026, compared to $5.8 million for the six months ended June 30, 2025. The decrease was primarily driven by a $0.6 million decrease in legal and professional fees, and a $0.4 million decrease in salaries and stock-based compensation and $0.1 million decrease in insurance expense, partially offset by a $0.4 million increase in audit and accounting fees, a $0.1 million increase in travel expenses, and a $0.4 million increase in other general and administrative expenses.

Added

Other Expense, Net

Added

Other expense, net decreased by $0.2 million or 8%, to $1.8 million for the six months ended June 30, 2026, compared to $2.0 million for the six months ended June 30, 2025. The decrease was primarily driven by a decrease of $0.9 million of expense for the net changes in fair value, loss upon conversion and extinguishment of convertible notes payable, partially offset by a decrease of $0.4 million in the gain upon a waiver of accrued interest, $0.1 million change on the gain on change in the fair value of warrants, and a $0.1 million change on the gain on the issuance of shares for services.

Added

For further details refer to Note 14 in the unaudited condensed consolidated financial statements included elsewhere in this document.

Added

Loss on Investment

Added

Loss on equity method investments was $0.2 million for the six months ended June 30, 2026. The loss was driven by a loss on the change in the carrying value of our investment in Sarborg with no comparable activity during the six months ended June 30, 2025.

Added

Interest Expense, Net

Added

Interest expense, net decreased by $167,000, or 72%, to $66,000 for the six months ended June 30, 2026, as compared to $233,000 for the six months ended June 30, 2025. The decrease was driven by a $102,000 million decrease of the from a decrease in the principal outstanding on the A.G.P. Convertible Note due to conversions and settlement during the six months ended June 30 2026, a $33,000 decrease as a result of the settlement of the August 2024 Nirland Note and October 2025 Nirland Note during the six months ended June 30, 2025, and a decrease of $65,000 million of debt issuance cost amortization related to the Convertible Promissory Note Payable, partially offset by $28,000 of interest expense related to the Ascent Note which was entered into during the three months ended June 30, 2026.

Reworded

Management assesses liquidity in terms of our ability to generate cash to fund operating, investing and financing activities. Since our inception, and in line with our growth strategy, we have prepared our financial statements assuming we will continue as a going concern. Since our inception, we have incurred net losses and experienced negative cash flows from operations. To date, our primary sources of capital have been through convertible debt, private placements of equity securities and the Sales Agreement with A.G.P., dated October 23, 2024, as amended.A.G.P. During the threesix months ended MarchJune 31,30, 2026 and 2025, we incurred operating losses of $3.7$6.7 million and $3.6$8.6 million, respectively.

Reworded

As consideration for the purchase, the Company has agreed to issue to the investors, in the aggregate: (i) 23,9202,392 shares of the Company’s Company’s Common Stock, exercise price of $0.0025$0.025 per share and (ii) pre-funded warrants (the to purchase up to 4,399,156439,915 shares of Common Common.Stock. In addition, the Company has agreed to pay Sarborg cash consideration of $8 million, with the cash portion of the consideration deferred until such time as the Company raises no less than $20 million through the use of an at-the-market facility program. As of MarchJune 31,30, 2026, the $8 million cash portion of consideration for our investment in Sarborg was still outstanding. We expect to raise the funds through an at-the-market facility program and repay the $8 million within 12 months of the issuance of the financial statements.

Reworded

During the threesix months ended March 31,June 30, 2026, the holder of the A.G.P. Convertible Note converted $0.7the remaining $2.5 million of principal and interest into 25,760 129,911 shares of the Company’s Common Stock, respectively. As of March 31, 2026, there was approximately $1.9 million in outstanding principal and interest remaining.Stock.

Reworded

The Note is payable to the Lender over twenty-four equal weekly installments of $82 thousand$82,000 commencing on JuneJuly 18,10, 2026, which may be paid in in cash or, at the option of the Company once an applicable resale registration statement is declared effective by the Securities and Exchange Exchange Commission covering the resale of any shares of the Company’s common stock, par value $0.0001 per share that may be received on on such conversion.

Added

Second Amendment to J.J. Astor Convertible Note

Added

On July 31, 2026, the Company entered into a second amendment to the J.J. Astor Note discussed in Footnote 7. The Company failed to make three scheduled weekly installment payments of $82,000 due July 17, July 24, and July 31, 2026, totaling $246,000, and had not filed the required resale registration statement by its deadline.

Added

Under this amendment, the lender agreed to treat these matters as an accommodation, rather than an event of default, but expressly reserved all rights if any future payment default occurs.

Added

In connection with the accommodation, the total principal balance was increased by a $378,000 restructuring premium, to a total amended principal balance due to J.J. Astor of $2.3 million and increased the default interest rate from 19% to 24% per annum upon any future event of default. The J.J. Astor Note is now payable in 23 weekly installments of approximately $104,000 commencing August 14, 2026 through a new maturity date of January 15, 2027.

Added

See Note 7 for further discussion of the J.J. Astor Note.

Removed

Ascent Note

Removed

On March 3, 2026, the Company entered into a Securities Purchase Agreement with Ascent Partners Fund LLC (“Ascent”) and issued a senior secured convertible promissory note (the “Ascent Note”) with a principal amount of approximately $0.6 million. Unless earlier repaid or converted in accordance with its terms, the Ascent Note was due to mature on July 3, 2026. The Company and Ascent may mutually agree to extend the maturity date by up to two months. The Ascent Note bears interest at 10% per annum and is secured by a first-priority security interest in the collateral pledged pursuant to the related security agreement and other transaction documents.

Removed

At any time following issuance, subject to the terms of the Ascent Note and receipt of the requisite stockholder approval under Nasdaq rules, Ascent may elect to convert all or any portion of the outstanding principal and accrued interest into shares of the Company’s common stock. Refer to Note 7 to our unaudited condensed consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q. As of March 31, 2026, approximately $0.6 million of principal and accrued interest remained outstanding but was subsequently repaid during the second quarter of 2026 and prior to the issuance of our March 31, 2026 unaudited condensed consolidated financial statements.

Reworded

We currently anticipate that cash required for working capital for the next 12 months is approximately $19.5$21.0 million, which includes forecasted research and development costs of $0.1 million,$40,000 forecasted general and administrative costs of $6.2$6.1 million, current liabilities of $11.2$12.5 million million and convertible promissory notes payable, if not converted prior to maturity of $2.0$2.4 million. We do not anticipate being able to fund required working capital for the next 12 months with cash and cash equivalents on hand and current borrowings. Management believes that that we will be able to fund cash required for the next 12 months through borrowings and equity raises. We have historically been able to to access funds through the issuance of debt, and more recently our at the market offering program through the Sales Agreement and believe we can continue to obtain funding through such debt financing agreements and Sales agreement as needed to meet cash requirements for the next 12 months.

Reworded

Net cash used in operating activities for the threesix months ended MarchJune 31,30, 2026, was $1.9$2.4 million, resulting primarily from a net loss of $4.1$8.7 million, adjusted for non-cash items including: a $0.3$0.7 million loss on the change in fair value of convertible notes payable, $1.0 $0.5 million of amortization expense, $0.5 million issuance of common stock for services, $0.3$0.6 million of amortization of directors and officers insurance, $0.2$0.4 million of stock-based compensation, a $0.1$1.1 million loss on debt extinguishment, $0.2 million loss on equity method investment, $0.1 million of non-cash lease expense, $0.1 million of non-cash interest expense and depreciationa expense.$1.5 million cash inflow from operating assets and liabilities. The net$1.5 million cash inflow from changes in operating assets and liabilities amountedis primarily due to toa $1.8 million cash inflow from accounts payable, a $0.4 million cash inflow from accrued expenses, partially offset by a $0.7 million cash outflow from prepaid expenses and other current assets and a $0.1 million.million cash outflow from operating lease liabilities.

Reworded

Net cash used in operating activities for the threesix months ended MarchJune 31,30, 2025, was $3.9$6.5 million, resulting primarily from a net loss of $4.8 $10.8 million, adjusted for non-cash items including a $1.8 million loss on the change in fair value of convertible notes payable, a $0.3 million gain on debt extinguishment, $0.3$0.4 million gain on waiver of accrued interest, a $0.1$0.3 million gain on debt extinguishment, $0.1 change in fair value of derivative warrant liability, $0.2a $2.9 million change in fair value of convertible notes, $1.8 million of amortization expense, $0.4 million of stock-based compensation expense,compensation, $0.2 million of non-cash interest expense, $0.2 million of amortization expense, $0.4 million of prepaid directors and officers insurance amortization and a $1.6$0.2 million cash outflow from operating assets and liabilities. The $1.6$0.2 million cash outflow from operating assets and liabilities is primarily due to a $0.7 $0.2 million cash outflow from accounts payable, a $0.2$0.1 million cash outflow from accrued expenses and other current liabilities,liabilities and a $0.3 $0.1 million cash outflow from operating lease liabilities, partially offset by a $0.2 million cash inflow from prepaid expenses and other current assets.

Reworded

No cash was used in investing activities for the threesix months ended MarchJune 31,30, 2026.

Reworded

Net cash used in investing activities for the threesix months ended MarchJune 31,30, 20252025, was $0.4 million, resulting from $0.4 million in diagnostic asset purchases and purchases of property, plant and equipment totaling $0.4 million.equipment.

Removed

Net cash provided by financing activities for the three months ended March 31, 2026, was $0.5 million, resulting from proceeds from the issuance of convertible notes payable.

Reworded

Net cash provided by financing activities for the threesix months ended MarchJune 31,30, 20252026, was $5.9$1.7 million, resulting from proceeds received from the issuance of convertible notes payable of $1.8 million, and from proceeds from the issuance of common shares related to the ATM program of $8.1$0.4 million.million, This waspartially offset by repayments of convertible notes payable of $1.6to million,related and repaymentsparties of notes payable of $0.6$0.5 million.

Added

Net cash provided by financing activities for the six months ended June 30, 2025, was $9.7 million, resulting from proceeds from the issuance of common shares related to the ATM program of $11.9 million, partially offset by repayments of notes payable of $0.2 million, repayments of notes payable – related parties of $0.4 million, repayment of convertible notes payable – related parties of $0.9 million, repayment of convertible notes payable of $0.7 million, and treasury stock purchases of $0.1 million.

Reworded

InvestmentsThe areCompany’s current investment is accounted for under the cost or equity method of accounting, under which the Company records its proportionate share of the investee’s earnings and losses within earnings and evaluates the investment for impairment when events or changes in circumstances indicate that the carrying amount may not be recoverable. The determination of whether a decline in value is other-than-temporary requires significant judgment regarding the investee’s financial condition, operating performance, business prospects, market conditions, and estimated recoverable value.

CDT insider buying and selling (Form 4)

Since 2026-04-11, insiders reported open-market purchases in 0 Form 4 filings and open-market sales in 2 filings (2 insiders, 2 trade dates, 2,068,290 shares, about $2.9M). Net open-market shares: -2,068,290 (purchases minus sales); net value about -$2.9M.Totals add up every open-market (code P and S) line in those filings, using the prices reported in the filings. Awards, option exercises, tax withholding and gifts are listed below but not counted.

Trade dateInsiderTransactionSharesPriceValueOwned afterFiling
2026-08-28Regan Andrew
Director, Chief Executive Officer
Other 5,436,830— —5,693,223 SEC
2026-08-28Regan Andrew
Director, Chief Executive Officer
Open-market sale 290— —5,692,933 SEC
2026-06-18Prospect Capital Securities Ltd
10% owner
Open-market sale 5,000$0.75 $3.8K593,289 SEC
2026-06-18Prospect Capital Securities Ltd
10% owner
Open-market sale 1,464,711$1.44 $2.1M0 SEC
2026-06-18Prospect Capital Securities Ltd
10% owner
Open-market sale 593,289$1.40 $830.6K0 SEC
2026-06-18Prospect Capital Securities Ltd
10% owner
Open-market sale 5,000$0.71 $3.5K1,464,711 SEC
2026-05-13Regan Andrew
Director, Chief Executive Officer
Grant/award 100,000$1.90 $190.0K256,393 SEC
2026-03-24Regan Andrew
Director, Chief Executive Officer
Grant/award 147,401— —156,393 SEC

Well-known investors holding CDT (13F)

InvestorQuarterSharesReported value% of their 13FChange vs prior quarter
Citadel Advisors (Ken Griffin) COM NEW2026-06-3032,295$18.1K0.0%New position
D. E. Shaw & Co. *W EXP 09/22/2022026-06-30375,000$4.1K0.0%No change

13F reports are filed up to 45 days after quarter end and show long U.S. equity positions only; options positions are omitted here.

Coming soon: email alerts when CDT files, watchlists and downloadable comparisons.